Evaluation of Excipient Effects on Desloratadine Syrup formulation as Impurity and pH

Objective: The aim of the research study is to compare the effects of excipient and pH and to develop a stable pharmaceutical product of desloratadine syrup formulation. For this stability study, 7 different formulation trial studies were prepared. In this study, different excipients were used and in this way different pH values were obtained to improve the product.

Methods: To improve the stability of desloratadine, 7 different formulations (F1-F7) were evaluated as different excipients, pH and impurities of desloratadine during the stability period. Each trial formulation was compared with pH and impurity results at different stability conditions at initial, 3rd month, 6th month.

Results: The most stable formulation study was evaluated within the pharmacopeia limits determined by comparing the stability results with each other in 7 different trial studies. According to the evaluation results, the F7 formulation was chosen as the most stable and best formulation in the studies.

Conclusion: According to the evaluation results, the F7 formulation was chosen as the most stable and best formulation in the studies.

Cite this article as: Ünal O. Evaluation of excipient effects on desloratadine syrup formulation as impurity and pH. Pharmata, 2023;3(2):35-40.